Particle Size Analysis of Aerosols from Medicinal Inhalers
نویسندگان
چکیده
Methods currently in use for the in-vitro measurement of the particle size distribution of aerosols from medical inhalers are reviewed with emphasis on their applicability both for product development and quality control testing and for simulation of likely performance in clinical use. Key attributes and limitations of the various techniques are identified, and consideration is also given both to likely developments to improve the capabilities of these analyzers as well as to the procedures for their
منابع مشابه
Electrostatics of pharmaceutical aerosols
Electrostatics of pharmaceutical aerosols for inhalation is a relatively new research area. Particle charges have been proposed to potentially influence deposition in the lungs but no conclusive in vivo data have been reported. Investigation of the relationship between the formulation and aerosol charging is required to further explore this area. The modified electrical low pressure impactor (E...
متن کاملCharacterisation of medicinal aerosols
Four commercially available medicinal aerosol products in India have been assessed for the aerosol size distribution at two different humidities using a ten stage cascape impactor device having a quartz crystal microbalance system. An indigenously made nebulizer in use in a city hospital has also been assessed for its aerosol efficiency. The size range is between 0.05 and 25 J.l,m. Mode in the ...
متن کاملPharmaceutical aerosols for the treatment and prevention of Tuberculosis
Historically, pharmaceutical aerosols have been employed for the treatment of obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease, but in the past decades their use has been expanded to treat lung infections associated with cystic fibrosis and other respiratory diseases. Tuberculosis (TB) is acquired after inhalation of aerosol droplets containing the bacilli f...
متن کاملParticle size study of nine metered dose inhalers, and their deposition probabilities in the airways.
This study deals with the particle size measurement of nine aerosol metered dose inhalers. Calibration was made possible by the use of a laser particle velocimeter (aerodynamic Particle Sizer from TSI). The count median aerodynamic diameters (CMAD) show little variation, from 0.63 to 0.73 micron, with standard deviations (sigma g) between 1.2 and 1.8. Aerodynamic diameter aerosol diagram analys...
متن کاملDust Particles and Aerosols: Impact on Biota “A Review” (Part III)
Natural resources play a fundamental role in the economy of country and create the situation to achieve the goals of sustainable society, these valuable resources have to be conserved and used with care. Destroying the forests and rangelands will lead to a dark future full of poverty, starvation and environmental pollution. Forests and rangelands play a considerable role in reducing air pollut...
متن کامل